Medications For Erectile Dysfunction

What are phosphodiesterase – 5 inhibitors?

The first PDE-5 inhibitor was Viagra sildenafil introduced in 1998. The WellMan Clinic was the first to import it into the UK. Originally intended to treat angina, it had become apparent that Viagra’s ability to dilate arteries had a better use for erectile dysfunction.

All PDE-5 inhibitors work in the same way, by stopping the breakdown of the chemical neurotransmitter which causes the dilation of the arteries in the penis. This neurotransmitter is produced at the end of nerves originating in the brain in response to arousal “input”. No arousal, no erection – even with a “Viagra”.

We now have four PDE-5 inhibitors to choose from:

1. Cialis (tadalafil) – effective for 36 hours
2. Vardenafil – effective for about 5 hours
3. Viagra (sildenafil) – effective for about 4 hours
4. Spedra (avanafil) – effective for 4 to 6 hours, quick acting

Of course, all four have mild side effects (due to other arteries dilating), the most bothersome being headache, flushing, nasal congestion, indigestion and occasionally muscular aches and pains. You will need to try each until you find a favourite.

The WellMan Clinic provides its patients with a prescription service for PDE-5 inhibitors. Patients can email or phone their orders to our staff, and collect or have them sent by post or courier. The only proviso is that they attend for a medication review at least annually.

Many men experiencing erectile dysfunction also have underlying low testosterone levels. At The WellMan Clinic, we offer comprehensive Testosterone Replacement Therapy (TRT) alongside ED treatments to address the root cause and improve long‑term sexual health and vitality. Learn more about our TRT services here.

Do not use the Viagras with other medications before discussion with your medical adviser.